منابع مشابه
Non-Inferiority Logrank Tests
Individuals are recruited during an accrual period of R years (or months or days). They are followed for an additional period of time until a total of T years is reached. Hence, the follow-up period is T-R years. At the end of the study, the non-inferiority logrank test is conducted at significance level α with power 1− β . Under the proportion hazards assumption, the hazard ratio HR = h2 / h1 ...
متن کاملNon-Inferiority Designs in A/B Testing
Most, if not all the current statistical literature on online randomized controlled experiments, (commonly referred to as “A/B Tests”), focuses on superiority designs. That is, the error of the first kind is formulated as incorrectly rejecting a composite null hypothesis of the treatment having no effect or having a negative effect. It is then controlled via a statistical significance threshold...
متن کاملMethods of defining the non-inferiority margin in randomized, double-blind controlled trials: a systematic review
BACKGROUND There is no consensus on the preferred method for defining the non-inferiority margin in non-inferiority trials, and previous studies showed that the rationale for its choice is often not reported. This study investigated how the non-inferiority margin is defined in the published literature, and whether its reporting has changed over time. METHODS A systematic PubMed search was con...
متن کاملChuanhu Anti-Gout Mixture versus Colchicine for Acute Gouty Arthritis: A Randomized, Double-Blind, Double-Dummy, Non-Inferiority Trial
BACKGROUND The Chuanhu anti-gout mixture has been used for many years in the treatment of gout in Chinese Traditional Medicine, and current methods for treatments for acute gouty arthritis have been either less effective or have had serious side effects. METHODS In this 12-week, double-blind, double-dummy, non-inferiority study, outpatient individuals with newly diagnosed acute gouty arthriti...
متن کاملEquivalence and non inferiority trials
Many effective drugs, biologics and devices exist. Because of this, it is often considered unethical to undertake placebo controlled clinical trials to evaluate new treatments. Rather, randomized active control noninferiority trials have become the norm. These trials, however, are accompanied by serious issues including selecting an active comparator, identifying previously run active comparato...
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2020
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2020.05.037